Dr Pascal J. Mosimann

Dr Pascal J. MosimannMD, PD

Neurointerventionalist

Associate Professor of Neuroradiology & Neurosurgery, University of Toronto

Fellowship Program Supervisor (Director), Interventional & Diagnostic Neuroradiology, Toronto Western Hospital (UHN)

I treat complex vascular diseases of the brain and spine through the blood vessels from the wrist, the groin or the neck, and invent devices to do it better, safer or faster. I mentor fellows from around the world to become trusted leaders.

Pushing hard when it helps, holding back when it doesn’t, speaking honestly with you throughout.

5,000+
Interventions as first operator
128
Peer-reviewed publications
30+
Countries fellows have come from

Training and practice

from the Swiss Alps to the shores of Lake Ontario (still searching for the mountains)

In conversation

“I spend my days in people’s heads but can’t read minds (yet), so I listen instead.”

Interventional neuroradiology, the work and how to build a career in it. Podcast Radiologists, episode 27 (University Medical Imaging Toronto).

Clinical focus

interventional neuroradiology (endovascular neurosurgery)

Pulsatile tinnitus

  • Pinpointing the arterial or venous cause CT and MR angiography and venography, catheter angiography
  • Venous sinus stenosis Pressure measurements and stenting
  • Sigmoid sinus wall or jugular bulb anomaly Sinus wall reconstruction (coils, intrasaccular devices) or stenting
  • Fistula or vascular tumour Targeted embolization

Venous and CSF disorders

  • Cerebral venous sinus thrombosis Mechanical thrombectomy and thrombolysis
  • Intracranial hypotension due to spinal CSF-venous fistula Transvenous embolization
  • Idiopathic intracranial hypertension / pseudotumor cerebri Venous sinus stenosis and stenting

Vascular malformations and fistulas

  • Brain & spine AVM Pressure cooker, transarterial & transvenous embolization
  • Dural arteriovenous fistula and carotid-cavernous fistula Embolization
  • Head and neck AVM or superficial venous malformations Percutaneous sclerotherapy, direct puncture or endovascular embolization

Subdural hematoma

  • Chronic subdural hematoma Middle meningeal artery embolization or MMAE

Oncology and epistaxis

  • Epistaxis or head and neck hypervascular tumours such as paraganglioma or hemangioma Pre-operative or standalone embolization

Aneurysms and subarachnoid hemorrhage

  • Brain aneurysm Balloon or stent-assisted coiling, flow diversion, intrasaccular devices
  • Ruptured aneurysm and subarachnoid hemorrhage Emergency coiling and intra-arterial vasospasm treatment

Stroke and arterial disease

  • Transient ischemic attack (TIA) / acute ischemic stroke Urgent assessment, clot removal / thrombectomy, stroke prevention
  • Carotid, vertebrobasilar, intracranial and subclavian artery stenosis and dissection Angioplasty, stenting

Diagnostic

  • Diagnostic cerebral and spinal angiography

Innovation and impact

Leadership

Program leadership

Fellowship Supervisor (Director) of the Interventional Neuroradiology Program at Toronto Western Hospital (UHN) and the University of Toronto.

Former Head of the Division of Neuroradiology at University Health Network (2022 to 2025).

Education

Course Director of PIKES, the pan-Canadian Karel ter Brugge educational symposium in interventional neuroradiology, neurology and neurosurgery.

Cross-appointments

Interventional neuroradiology staff at the Hospital for Sick Children (SickKids), with a Neurosurgery cross-appointment at the University of Toronto.

Service

Former stroke-centre certification auditor, national board examiner and Editorial Board member (Journal of Neuroradiology).

Industry

Proctor and consultant for multiple medtech companies.

How I practice and why I do this

I have been a patient too. That vulnerability, and the worry about whether you will wake up the same, is an anxiety your family carries with you. Surrendering and trusting someone you barely know in that moment takes real courage. Each patient I counsel or operate on, whatever their story, is approached with the same care and focus as a member of my own family. I take a genuine interest in the person, not only the disease, and I listen for what is said and for what is not: a hesitation, a question left unasked, what a relative adds, how someone carries themselves in the room. I want every patient to feel, beyond any doubt, that they are cared for. Brain and spine diseases can be frightening, and when I study your chart and images, I do it with a deep sense of responsibility and compassion. That is the standard I hold myself to, and the one I try to pass on.

Many of the patients who reach me have been told their case is too difficult, or have already had a treatment that did not work. I do not give up easily, and I will keep looking for a way when others have stopped. That is how I have been able to treat, and often cure, people who were told nothing more could be done. Persistence is not the same as taking chances. I prepare meticulously, I put safety ahead of ambition, and I have learned to recognise when the wisest decision is not to proceed. I cannot promise a perfect outcome for everyone, but I can promise that every avenue will have been weighed with judgement and care.

Just as often, the right course is not to intervene at all. For many conditions, treatment risk, however small, can outweigh that of the disease's natural history, and careful observation with regular follow-up may be the wiser path. Knowing when not to treat is as much a part of the work as knowing how. And not every problem has a clear cause or a solution I can offer. With long-standing symptoms especially, I will look thoroughly, but I will be honest about what can and cannot be helped, rather than raise hopes I cannot meet.

Complications can occur. Medicine does not always go the way we hope. When it does not, I do not step back. I stay with the patient and the family, and I carry those moments with me.

I am still captivated, every time, when a catheter introduced through a tiny hole in the wrist or the groin reaches the deepest part of the brain. I love the puzzle of a difficult case, working it like a riddle and executing it with artful precision. I am drawn to the leading edge, and to helping develop the technology that takes us there.

Among the deepest joys of my work is mentoring. Teaching matters to me for the same reason the bedside does: putting the small, hard-to-teach details into words, so fellows understand and integrate them faster, growing into independent thinkers ready to face the unexpected with humility, judgement and creativity. Like a sensei, I love watching hesitant trainees blossom into sure-handed experts, their eyes widening with exhilaration at each transformative aha moment, as they turn into masters I may learn from as well.

After completing his training in Paris, my friend and co-fellow Dr Eugen Enesi built interventional neuroradiology in Albania from almost nothing, and I was glad to help where I could.

Some of the best in the field trained me, and gave me the room to push myself as far as I could. What I want now is simple: to keep building new tools with the engineers who bring them to patients, to help others treat neurovascular diseases well, and to give back to those who need it most.

Ways to collaborate

Clinical program leadershipBuilding and directing neurovascular services and interventional-neuroradiology fellowship training.
Device development and evaluationFrom concept and bench models through first-in-human and clinical assessment.
Investigator-initiated trialsRegistries and prospective studies run as principal investigator.
Proctoring and educationCase proctoring, course direction, and hands-on training.

If you are a physician with a complex or previously untreatable case, a trainee, or a builder working on the next tool, I would like to hear from you. Reach me at pascal.mosimann@uhn.ca or on LinkedIn.

For referrals. Physicians can refer a patient to our multidisciplinary neurovascular clinic and interventional neuroradiology service by fax at +1 416 603 4257, or by email. Patients: please ask your physician to send a referral.

Email a referral