Dr Pascal J. Mosimann

Dr Pascal J. MosimannMD, PD

Neurointerventionalist

Associate Professor of Neuroradiology & Neurosurgery, University of Toronto

Senior Staff & Fellowship Program Supervisor (Director), Interventional & Diagnostic Neuroradiology, Toronto Western & Toronto General Hospitals

University Health Network — Newsweek’s #2 hospital in the world (2026). University of Toronto — 2nd in the world in clinical medicine (NTU 2025).

I treat complex vascular disease of the brain and spine from inside the vessels, and I invent the tools that make it possible.

More than 4,000 interventions as first operator; neurovascular device inventor and patent holder; established researcher and mentor.

Training and practice

from the Swiss Alps to Europe and the shores of Lake Ontario

Clinical focus

interventional neuroradiology (endovascular neurosurgery)
  • Aneurysms & flow diversion
  • Brain AVM curative embolization
  • Chronic subdural (MMA embolization)
  • CSF-venous fistula
  • Dural & carotid-cavernous fistulas
  • Head & neck / tumour embolization
  • Pediatric neurointervention
  • Pulsatile tinnitus & venous disease
  • Stroke thrombectomy
  • Vascular-malformation sclerotherapy

Leadership. Former Head of the Division of Neuroradiology at University Health Network, Toronto General and Western (2022–25), and, since 2024, formally Fellowship Program Supervisor (Director) of the interventional neuroradiology program at the University of Toronto. Course Director of PIKES, the pan-Canadian Karel ter Brugge educational symposium in interventional neuroradiology, neurology and neurosurgery. Former stroke-centre certification auditor, national board examiner and Editorial Board member (Journal of Neuroradiology). Proctor and consultant for multiple medtech companies.

Innovation and impact

  • Pressure cooker technique
    A curative embolization method for brain arteriovenous malformations, co-developed with René Chapot and now used worldwide.
  • Robotic endovascular navigation
    Co-invention of MAGFLOW, a flow-driven magnetic microcatheter for remote superselective navigation and embolization, published in Science Robotics (2025) and Nature Communications (2020).
  • Patents and mentoring
    Two device patents, a photoactivated liquid embolic for aneurysms and an enhanced-torque steerable guidewire; and dozens of interventional-neuroradiology fellows trained since 2012, from more than 30 countries, many now leaders in the field.
Cumulative peer-reviewed output, reaching 128 publications
20112026

Beyond the clinic

I have been the patient too, and I know how it feels to go under not knowing if you will wake up the same. Each patient I counsel or operate on is approached with as much care and focus as I would with a member of my own family. Brain and spine diseases can be frightening, and I see the person living through it in even more detail as I look at their scans. That is the standard I hold myself to, and the one I try to pass on.

Where interventional neuroradiology / endovascular neurosurgery is still young, I have worked to help it take root, supporting programs across the continents, some alongside my former Paris co-fellow, Dr Eugen Enesi, as he built his own, and others led by fellows who trained with me and carried the field home. Teaching matters to me for the same reason the bedside does: putting the small, hard-to-teach details into words, so trainees understand and integrate them faster, growing into independent leaders and thinkers, ready to face the unexpected, armed with patience, humility, a caring heart, a sharp mindset and the skillset and abilities to be creative.

Some of the best in the field trained me, and gave me the room to push myself as far as I could. What I want now is simple: to keep surpassing myself, building new tools with the engineers who bring them to patients, and help others treat neurovascular diseases well, giving back to the people in pain or just starting out, who need it most.

Ways to collaborate

Clinical program leadershipBuilding and directing neurovascular services and interventional-neuroradiology fellowship training.
Device development and evaluationFrom concept and bench models through first-in-human and clinical assessment.
Investigator-initiated trialsRegistries and prospective studies run as principal investigator.
Proctoring and educationCase proctoring, course direction, and hands-on fellow training.

To discuss working together, reach me at pascal.mosimann@uhn.ca or connect on LinkedIn.